Title: Research Assistant
Department: School of Medicine, Department of Endocrinology/ Surgery
Tenure: Fulltime, specified purpose contract for up to 18 months, with the potential for extension
Location: Royal College of Surgeons in Ireland (RCSI), 123 St. Stephens Green, Dublin 2, Ireland
Reporting to: Prof Michael O’Reilly and Dr. Marie McIlroy
Salary: Aligned to level 1 of the IUA research salary scale
Proposed Start Date: 5th December, 2022
We currently seek a research assistant to develop an exciting and innovative project involving the creation of a novel 3D bioprinting model to dissect the impact of androgen excess on skeletal muscle energy metabolism in women with Polycystic Ovary Syndrome (PCOS). PCOS is a chronic metabolic disorder, affecting 10-13% of all women. PCOS is associated with a significantly increased risk of type 2 diabetes mellitus and cardiovascular disease. Metabolic perturbations in this disorder are intrinsically linked to androgen excess. There are currently no disease-specific treatments to modify metabolic risk in women with PCOS.
The project builds on the existing expertise in terms of 3D bioprinting patient derived material within Dr. Mcllroy’s group alongside Professor O’Reilly’s world-leading clinical expertise on PCOS associated metabolic dysregulation. The successful applicant will be guided by both Prof O’Reilly and Dr. Mcllroy to develop highly novel ex vivo models by applying 3D bioprinting to patient-derived tissues from PCOS patients taking part in on-going clinical trials. The programme of work will establish a highly innovative biological model to dissect the metabolic consequences of androgen excess in this condition.
Specifically, the duties of the post are:
• Perform research as directed by both principal investigators
• Work productively with other research team members in a collegiate manner and contribute towards the progress of the research project
• Apply experimental and analytical strategies to carefully manage any data generated for presentations and peer-review publications
• Contribute to research team meetings
• Applicants should have a minimum of 2:1 undergraduate degree (required) AND/OR Post- graduate degree (desirable) in a relevant biological subject.
Knowledge & Experience – (Essential):
• Knowledge and experience of current molecular and cell biology techniques.
• Self-motivated, hard-working and willing to contribute towards research in the area of Polycystic Ovary Syndrome.
• Effective communication style, proficient in report writing and good presentation skills.
Knowledge & Experience (Desirable):
• Experience in aseptic tissue culture practices handling such as cell culture, cell counting and seeding, resuscitation of frozen cell stocks etc.
• Any prior experience of working with clinical samples would be beneficial.
• Knowledge in molecular and cell biology- based assays such as proliferation assay, microscopy and ELISA. and experience in nucleic acid isolation, protein extraction and quantification
Please apply online no later than 5pm on the closing date with your CV and Cover Letter. Applications must be made online, applications made by email or after the closing date will not be considered.
Questions can be addressed to Prof O’Reilly (email@example.com) or Dr McIlroy (firstname.lastname@example.org)
This job description may be subject to change to reflect the evolving requirements of the Department and RCSI in developing healthcare leaders who make a difference worldwide.
Similar vacancies that arise in the next 6 months may be filled from the pool of applicants that apply for this position.
Employees are required to undertake 6 months service in their current role before applying for other internal opportunities, unless agreed in advance by the SMT representative.
RCSI is proud to be an equal opportunity employer and welcome applications from all suitably qualified persons regardless of their gender, civil status, family status, sexual orientation, religion, age, disability or race.
If you have any particular requirements for your interview, please notify the Human Resources Department at your earliest convenience.